OsteoDenx®, a patented US innovation, offers a breakthrough in bone and joint health supplements. Its unique Syno-PORTIN® Complex, enriched with milk-derived R-ELF, targets the synovium for effective nutrient delivery. This scientifically-proven formula enhances bone mineral density, supports joint cartilage integrity, and ensures optimal nutrient balance for a robust skeletal system, outperforming traditional vitamin and mineral supplements in absorption and integration.
OsteoDenx®
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Transformed Lives, True Stories
Bio-Replenishment® for Bone and Joint Health
OsteoDenx®, a patented bone and joint health formula, features the innovative Syno-Portin® Complex for targeted nutrient delivery. This unique system, based on ribonuclease-enriched lactoferrin (R-ELF), combines bioactive proteins lactoferrin and ribonuclease, offering multifaceted health benefits through a distinct mechanism of action.
In a rigorous, IRB-approved clinical trial, R-ELF, a key component of synovial fluid influencing bone turnover, was tested against a calcium/vitamin D placebo. Results, published in leading medical journals, showed that R-ELF significantly enhanced osteoblastic activity, optimized bone resorption, and improved joint comfort within six months, outperforming the placebo group.
In a rigorous, IRB-approved clinical trial, R-ELF, a key component of synovial fluid influencing bone turnover, was tested against a calcium/vitamin D placebo. Results, published in leading medical journals, showed that R-ELF significantly enhanced osteoblastic activity, optimized bone resorption, and improved joint comfort within six months, outperforming the placebo group.
Bio-Replenishment® for
Bone and Joint Health
OsteoDenx®, a patented bone and joint health formula, features the innovative Syno-Portin® Complex for targeted nutrient delivery. This unique system, based on ribonuclease-enriched lactoferrin (R-ELF), combines bioactive proteins lactoferrin and ribonuclease, offering multifaceted health benefits through a distinct mechanism of action.
In a rigorous, IRB-approved clinical trial, R-ELF, a key component of synovial fluid influencing bone turnover, was tested against a calcium/vitamin D placebo. Results, published in leading medical journals, showed that R-ELF significantly enhanced osteoblastic activity, optimized bone resorption, and improved joint comfort within six months, outperforming the placebo group.
Bioactive Matrix
Lactoferrin-(TCR)
Enhances absorption &
delivery of nutrients
Collagen
Boosts flexibility &
supports joint function
Vitamin K2
Promotes blood flow &
bone remodeling
Vitamin D3
Improves calcium uptake &
strengthens bones
Boswellia
Eases joint pain & protects cartilage
Bioactive Matrix
Lactoferrin-(TCR)
Enhances absorption & delivery of nutrients
Collagen
Boosts flexibility & supports joint function
Vitamin K2
Promotes blood flow & bone remodeling
Vitamin D3
Improves calcium uptake & strengthens bones
Boswellia
Eases joint pain & protects cartilage
- Patented Technology
- Proven Formula
OsteoDenx® is a first-in-class supplement crafted to effectively support both bones and joints. Powered by patented Syno-Portin Complex® with ribonuclease-enriched lactoferrin, it is clinically proven to reinforce the entire skeletal system. It is fortified with a balanced blend of collagen, boswellia, resveratrol, vitamins and minerals.
This dual-action makes OsteoDenx® an exemplary choice for bone and joint health, embodying the full potential of a two-in-one formula.
All Natural
Non-GMO
Lactose-Free
Gluten-Free
Soy-Free
No Preservatives
Amount per Serving
% DV
Copper (as sulfate)
0.5 mg
55
Vitamin D3 (as Cholecalciferol)
10 µg
50
Maganese (as sulfate)
1 mg
43
Selenium (as Selenomethionine)
22 µg
40
Vitamin K2 (as Menaquinone, MK7)
37.5 µg
31
Folate (as Folic acid)
100 µg.DFE
25
Syno- PORTIN® Complex
RNase-enriched lactoferrin (R-ELF) +
Collagen peptides (from fish) +
Boswellia (from Boswellia serrata)
350 mg
⊹
Trans-Resveratrol
10 mg
⊹
Other Ingredients:
Vegetable capsules, Rice flour, Calcium carbonate, Magnesium stearate, Silicon dioxide, Citric acid & Sodium bicarbonate.
⊹ Daily Value not established
Why OsteoDenx®?
What is OsteoDenx®?
OsteoDenx® is an exclusive bone and joint health technology – with a unique mechanism of action that provides several health benefits. This advanced formula was granted protection of four US patents. OsteoDenx® contains Syno-Portin® Complex, a novel targeted nutrient delivery system based on ribonuclease-enriched lactoferrin (R-ELF). R-ELF is a precisely calibrated mixture of two multi-functional bioactive proteins sourced from milk, specifically lactoferrin and ribonuclease (a.k.a. angiogenin or RNAse types 2 and 4).
R-ELF is a vital component of the synovial fluid that plays an important role in bone turnover. The bone and joint health benefits of R-ELF (Active group) was evaluated and compared to calcium/vitamin D supplementation (placebo group). In an IRB-approved, randomized, double-blind, placebo-controlled human clinical study, participants administered R-ELF demonstrated a statistically significant increase in osteoblastic activity, optimized bone resorption and reported improvement in joint comfort within six months compared to placebo group. The study results were published in top-tier, peer-reviewed medical journals.
How does it work?
Bone Strength - OsteoDenx® is a revolutionary supplement clinically proven to improve bone strength and density. This innovative formula, powered by patented SynoPortin® Complex, promotes bone formation by stimulating osteoblasts and minimizes bone loss by regulating osteoclast activity, ensuring balanced bone remodeling essential for maintaining skeletal integrity. In addition to its cellular benefits, OsteoDenx® effectively improves the body’s absorption and utilization of vital bone nutrients, particularly calcium. This combination of cellular support and nutrient optimization positions OsteoDenx® as a comprehensive solution for sustaining and enhancing bone health, laying a solid foundation for overall skeletal wellness.
Joint Relief - OsteoDenx® is a powerful supplement for joint support, scientifically designed to bolster chondrocytes, the cells crucial for maintaining cartilage health. The distinct formula is also highly effective in mitigating inflammation, a major contributor to joint discomfort and stiffness, thereby improving joint comfort and increasing flexibility. Beyond immediate relief, OsteoDenx® plays a crucial role in safeguarding cartilage structure, fostering enduring healthy joint function. Its advanced ability to neutralize free radicals effectively provides sustained protection against oxidative stress, paving the way for long-term, pain-free mobility and peak joint performance.
Why do you need it?
The concern for a healthy skeletal system affects people of all age, sex, diet, lifestyle, etc. Therefore, it is important for all individuals to take proactive steps to ensure a healthy skeletal system, following an active lifestyle and a complete diet.
- Active Lifestyle - The strength of bones and joints depend on a ‘use it or lose it’ principle. If an individual is sedentary or obese, such condition may lead to a weak skeletal system. On the other hand, if an individual overuses bones and joints causing excessive ‘wear and tear’, then he or she might face similar consequences. Regular and moderate weight-bearing exercise is recommended to avoid such scenarios.
- Complete Diet - Diet provides the energy and ‘building blocks’ to maintain the skeletal structure and function. The body has specific pathways that convert these dietary ‘building blocks’ into its own multi-functional regulatory molecules known as bio-replenishments. Lactoferrin and ribonucleases are bio-replenishments naturally produced inside the body. An individual normally produces these molecules to meet physiological demand (i.e. bio-replenishment levels are in balance). However, due to various factors such as poor diet, stressful lifestyle, aging, an individual may show a decline in bio-replenishment synthesis and/or utilize in excess. Supplementing the body with bio-replenishments can support total body wellness.
It can be challenging to keep an active lifestyle and complete diet all the time. Therefore, adding OsteoDenx® to a daily nutritional regimen is a proactive approach to maintain healthy bones and joints.
Recommended Use
Take 1 (ONE) capsule by mouth per day with or without food preferably at bedtime. Take double the recommended dosage during first month of use. Also, depending upon lifestyle, age and health-status, increasing the dosage to two or three capsules by mouth per day can also be taken.
Study I: Provide Joint Relief
- Overview
- Results
Bone and joints work together to enable movement, similar to a joist and lever system. For optimal function, the joints have to preserve structure, maintain lubrication (i.e. synovial fluid) and remove debris (normal by-product of wear-and-tear). The body relies on the immune system to protect the joints by continuously monitoring its status; when there is excessive wear-and-tear, the immune system triggers the release of several cytokines to indicate a 'high alert' state. Optimal joint health can only be achieved when these processes are addressed and in balance.
A six-month, randomized clinical study was conducted on 35 healthy, post-menopausal women, aged 45 to 60 years. They were randomized into placebo or R-ELF supplement group; the R-ELF group was supplemented with R-ELF (2x 125 mg/day) and calcium (100% RDA), while the placebo group received only the calcium supplement. Serum levels of receptor activator for NF-κB ligand (RANKL), C-reactive protein (CRP) and various other cytokines were determined by ELISA. IL-6 and TNF-α decreased significantly (-44% and -10% respectively) while IL-10 increased (140%) with R-ELF supplementation. RANKL and CRP were modestly reduced (-50%) relative to the placebo, while RANKL elevated initially. R-ELF supplementation showed beneficial effects on joint health.
Reference: Bharadwaj S, Tezus Naidu AG, Betagiri GV, Prasadarao NV, Naidu AS (2010) Milk ribonuclease-enriched lactoferrin supplementation in women. J Infl Res 59(11):971-978..
Other Joint Supplements
Less Joint Relief
OsteoDenx®
1.5X Joint Relief
Study II: Improve Bone Density
- Overview
- Results
The bone is a dynamic tissue that undergoes a continuous remodeling process through repeated cycles of destruction and rebuilding. In healthy adults, the amount of new bone formation approximately balances the amount of bone resorption. As age increases, and due to factors such as diet, lifestyle, medications, etc., the balance shifts to favor bone resorption. A reduction in angiogenesis could also contribute to this imbalance. Maintaining healthy bone turnover is essential to reinforce skeletal structure and optimize its function.
A total of 35 healthy, post-menopausal women, aged 45 to 60 years, were randomized into placebo or R-ELF supplement group. Over a six-month period, the bone status was monitored by assessing bone resorption markers, serum N-telopeptides (sNTx) and urine deoxypyridinoline (uDpd) cross-links; and serum bone formation markers, bone-specific alkaline phosphatase (SBAP) and osteocalcin (sOC). R-ELF supplmentation demonstrated a decrease in uDpD levels by 14% (19% increase in placebo) and sNTx maintained at 25% of the baseline (41% for placebo), while serum BAP and OC levels showed a 45% and 16% elevation (25% and 5% for placebo). R-ELF supplementation showed positive effects on healthy bone turnover.
Reference: Bharadwaj S, Tezus Naidu AG, Betagiri GV, Prasadarao NV, Naidu AS (2009) Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers. Osteo Int 20(9):1603-1611.
Other Bone Supplements
Less Bone Density
OsteoDenx®
3X Bone Density
Study I: Provide Joint Relief
- Overview
- Results
Bone and joints work together to enable movement, similar to a joist and lever system. For optimal function, the joints have to preserve structure, maintain lubrication (i.e. synovial fluid) and remove debris (normal by-product of wear-and-tear). The body relies on the immune system to protect the joints by continuously monitoring its status; when there is excessive wear-and-tear, the immune system triggers the release of several cytokines to indicate a 'high alert' state. Optimal joint health can only be achieved when these processes are addressed and in balance.
A six-month, randomized clinical study was conducted on 35 healthy, post-menopausal women, aged 45 to 60 years. They were randomized into placebo or R-ELF supplement group; the R-ELF group was supplemented with R-ELF (2x 125 mg/day) and calcium (100% RDA), while the placebo group received only the calcium supplement. Serum levels of receptor activator for NF-κB ligand (RANKL), C-reactive protein (CRP) and various other cytokines were determined by ELISA. IL-6 and TNF-α decreased significantly (-44% and -10% respectively) while IL-10 increased (140%) with R-ELF supplementation. RANKL and CRP were modestly reduced (-50%) relative to the placebo, while RANKL elevated initially. R-ELF supplementation showed beneficial effects on joint health.
Reference: Bharadwaj S, Tezus Naidu AG, Betagiri GV, Prasadarao NV, Naidu AS (2010) Milk ribonuclease-enriched lactoferrin supplementation in women. J Infl Res 59(11):971-978..
Other Joint Supplements
Other Joint Supplements
Less Joint Relief
OsteoDenx®
150% Joint Relief
Study II: Improve Bone Density
- Overview
- Results
The bone is a dynamic tissue that undergoes a continuous remodeling process through repeated cycles of destruction and rebuilding. In healthy adults, the amount of new bone formation approximately balances the amount of bone resorption. As age increases, and due to factors such as diet, lifestyle, medications, etc., the balance shifts to favor bone resorption. A reduction in angiogenesis could also contribute to this imbalance. Maintaining healthy bone turnover is essential to reinforce skeletal structure and optimize its function
A total of 35 healthy, post-menopausal women, aged 45 to 60 years, were randomized into placebo or R-ELF supplement group. Over a six-month period, the bone status was monitored by assessing bone resorption markers, serum N-telopeptides (sNTx) and urine deoxypyridinoline (uDpd) cross-links; and serum bone formation markers, bone-specific alkaline phosphatase (SBAP) and osteocalcin (sOC). R-ELF supplmentation demonstrated a decrease in uDpD levels by 14% (19% increase in placebo) and sNTx maintained at 25% of the baseline (41% for placebo), while serum BAP and OC levels showed a 45% and 16% elevation (25% and 5% for placebo). R-ELF supplementation showed positive effects on healthy bone turnover.
Reference: Bharadwaj S, Tezus Naidu AG, Betagiri GV, Prasadarao NV, Naidu AS (2009) Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers. Osteo Int 20(9):1603-1611.
Other Bone Supplements
Less Bone Density
OsteoDenx®
3X Bone Density
Not all Bone and Joint Supplements are Equal
Not all Bone and Joint Supplements are Equal
| | | | | | | |
| Promotes Bone Growth | | | | | | |
| Maintains Bone Density | | | | | | |
| Improves Joint Mobility | | | | | | |
| Supports Mineral Balance | | | | | | |
| Optimizes Nutrient Absorption | | | | | | |
| Easy One Capsule / Day Dose | | | | | | |
| Patented Technology | | | | | | |
| Clinically-Proven Formula | | | | | | |
| All Natural Ingredients | | | | | | |
| Ideal for All Ages (Depends) | | | | Dose | | |
Your Questions - Answered
What are Bio-Replenishments?
Bio-replenishments are bio-active molecules that are produced and expended by the body on a regular basis. Examples include insulin, hormones, lactoferrin and ribonuclease. These molecules regulate our metabolism and maintain physiological balance or ‘homeostasis’. Any deficiency or dysfunction of bio-replenishments manifests as disorder(s), disease(s) or death.
What is OsteoDenx®?
OsteoDenx® is a patented, clinically-proven, dual-action supplement designed to enhance both bone and joint health. It strengthens the skeletal system, improves bone density, and regulates bone remodeling process. Additionally, OsteoDenx® promotes the absorption and utilization of vital bone nutrients, particularly calcium, ensuring optimal skeletal wellness. This comprehensive support makes OsteoDenx® an essential foundation for overall skeletal health.
What is R-ELF?
Ribonuclease-Enriched Lactoferrin (R-ELF) or Lactoferrin and ribonuclease are proteins naturally produced inside the body. They co-exist in milk and other biological fluids as key regulatory molecules with specific role in various physiological pathways. From a skeletal system perspective, the proteins combined help promote healthy bone turnover and maintain healthy joints.
What are the health benefits of taking OsteoDenx®?
Regular intake of OsteoDenx® helps in the formation of healthy bone tissue, supporting healthy bone density, protecting and lubricating joints, and enhancing the absorption of essential nutrients.*
Who can benefit from OsteoDenx®?
OsteoDenx® is crafted for individuals of all ages, irrespective of their dietary habits or daily routines. It is particularly advantageous for those who face challenges such as joint discomfort, limited mobility, weak bones, or poor nutrient absorption. OsteoDenx® provides targeted support for optimal bone and joint health, making it a valuable addition to your daily regimen to maintain a robust skeletal system.
What makes OsteoDenx® unique?
The technology in OsteoDenx® is backed by over forty years of scientific research, two human clinical studies with published results and four US patents. OsteoDenx® is distinct from other generic vitamins or supplements because it helps support the body’s own process of building new bone tissue and lubricating joints for optimal mobility. In complementing this natural bone remodeling and repair process, OsteoDenx® can help promote strong, healthy bones and joints throughout life.
How is OsteoDenx® made?
OsteoDenx® is manufactured in Europe in a government certified manufacturing facility that meets current good manufacturing practices (cGMP) standards. Only the highest quality ingredients are sourced and third-party tested for purity. All ingredients also undergo meticulous testing at each stage of the production process, resulting in the safest, highest quality product.
Can individuals with lactose-intolerance take OsteoDenx®?
Yes. There is NO lactose sugar in OsteoDenx®.
Can individuals with milk protein allergy take OsteoDenx®?
Yes. Milk proteins that are reportedly associated with allergic reactions are: casein, casein derivatives (sodium and/or calcium-based), lactalbumin, beta-lactoglobulin and bovine serum albumin. R-ELF does not belong to this group of milk allergens. To our knowledge - any R-ELF associated or R-ELF mediated milk protein allergic reactions in human subjects has not been reported. However, if the person has any medical condition (including any milk protein allergy), it is advisable to consult with that person’s health care provider before use of this or any supplement.
Can individuals with gluten and/or soy intolerance take OsteoDenx®?
Yes. There is NO gluten or soy in OsteoDenx®.
Can pregnant women take OsteoDenx®?
Yes, a pregnant woman may take OsteoDenx®. However, a woman with any medical condition (including pregnancy) should consult a healthcare provider before using any supplements.
Can children take OsteoDenx®?
Yes, a child above the age of 4 may take OsteoDenx®. However, it is advisable to consult with the child’s health care provider before use of this or any supplement
What is the suggested dosage for OsteoDenx®?
The recommended dosage for OsteoDenx® is to take two capsules daily for the first month. After the first month, the dosage can be reduced to one capsule per day. However, some individuals, such as athletes, the elderly, and post-menopausal women, may benefit from continuing to take two capsules per day.
Should OsteoDenx® be taken with food or on an empty stomach; daytime or bedtime?
It is recommended to take OsteoDenx® at bedtime with or without food (because the mineral metabolism is most active during sleep).
Can OsteoDenx® be taken with other dietary supplements and medications?
Yes, you can take OsteoDenx® with other dietary supplements. However, if you have any medical conditions or are on medication, it's best to consult your healthcare provider before use.
Should OsteoDenx® not be taken with certain types of medications?
If a person has any medical condition (under any medication), it is advisable to consult with that person’s health care provider before use of this or any supplement.
Can OsteoDenx® be taken together with alcoholic beverages?
No. However, OsteoDenx® can be spaced at least 12 hours before or after consumption of an alcoholic beverage.
Can OsteoDenx® be taken together with hot beverages or foods?
No. However, OsteoDenx® is relatively stable at high temperatures and it is OK to consume this protein supplement with warm foods.
What are the side effects from taking OsteoDenx®?
No side effects have been reported with OsteoDenx®. However, if any discomfort is noticed by consuming OsteoDenx® immediately stop taking the product and consult your primary health care provider.